The character debuted as an antagonist of the titular mutant superhero team in X-Men #12–13 (July & September 1965). In the first of these issues, he rampaged unseen throughout the X-Men's headquarters while the team's leader, Professor X, related the character's origin in a series of flashbacks.
After an initial defeat in the following issue, the Juggernaut returned in X-Men #32–33 (May–June 1967), and returned again in X-Men #46 (July 1968), then fought the sorcerer Doctor Strange in Doctor Strange #182 (September 1969), X-Men member the Beast in Amazing Adventures #16 (January 1973), and the Hulk in The Incredible 'Hulk #172 (February 1974).
After the canceled X-Men returned in the mid-1970s, the Juggernaut returned to fight a new iteration of the team in X-Men #101–103 (October 1975–February 1976). Storylines in Spider-Woman #37–38 (April & June 1981) and The Amazing Spider-Man #229–230 (June–July 1982) explored the Juggernaut's relationship with his ally Black Tom Cassidy.
The X-Men and Spider-Man proved to be regular foes for the character, who appeared in Uncanny X-Men #183 (July 1984), Marvel Team-up #150 (February 1985), and Uncanny X-Men #194 (June 1985). The Juggernaut guest-starred in Secret Wars II #7 (January 1986), battled a new generation of mutants in X-Men #217–218 (April & June 1987), appeared in a flashback story in Marvel Saga #21 (August 1987), and in a humorous episode in Excalibur #3 (December 1988).
The Juggernaut also participated in the "Acts of Vengeance" storyline in Thor #411–412 (December 1989) and returned in Thor #429 (February 1991). Other appearances included an encounter with his creator, Cyttorak, in X-Men Unlimited #12 (September 1996) and starring in the one-shot issue Juggernaut #1 (April 1997).
In 1994, Marvel purchased Malibu Comics and began a series of crossovers that saw Marvel characters entering the Malibu Ultraverse. In 1995-1996, Juggernaut lead a group of Ultras, who were named The All New Exiles. The All New Exiles eventually met up with the X-Men in a special Malibu/Marvel collaboration, The All New Exiles vs X-Men, Issue #0, dated October 1995.
The character appeared in Juggernaut: The Eighth Day #1 (November 1999) and Avengers Vol. 3, Nos. 23–25 (December 1999–February 2000) with similarly powered avatars and attempted a reformation in Uncanny X-Men # 410–413 (September–December 2002) and X-Men #162–164 (November 2004–January 2005). The Juggernaut confronted his stepbrother, Charles Xavier—leader of the X-Men—in X-Men: Legacy #219 (February 2009), and fought the Hulk in Hulk #602 (November 2009).
He appeared as a regular character in Thunderbolts beginning with issue #144, and remained on the team until issue #158, during the Fear Itself limited series.